Please use this identifier to cite or link to this item: http://hdl.handle.net/11718/25286
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dc.contributor.authorKar R.
dc.contributor.authorJha S.K.
dc.contributor.authorOjha S.
dc.contributor.authorSharma A.
dc.contributor.authorDholpuria S.
dc.contributor.authorRaju V.S.R.
dc.contributor.authorPrasher P.
dc.contributor.authorChellappan D.K.
dc.contributor.authorGupta G.
dc.contributor.authorKumar Singh S.
dc.contributor.authorPaudel K.R.
dc.contributor.authorHansbro P.M.
dc.contributor.authorKumar Singh S.
dc.contributor.authorRuokolainen J.
dc.contributor.authorKesari K.K.
dc.contributor.authorDua K.
dc.contributor.authorJha N.K.
dc.date.accessioned2022-02-11T10:14:42Z-
dc.date.available2022-02-11T10:14:42Z-
dc.date.issued2021
dc.identifier.citationKar, R., Jha, S. K., Ojha, S., Sharma, A., Dholpuria, S., Raju, V. S. R., Prasher, P., Chellappan, D. K., Gupta, G., Kumar Singh, S., Paudel, K. R., Hansbro, P. M., Kumar Singh, S., Ruokolainen, J., Kesari, K. K., Dua, K., & Jha, N. K. (2021). The FBXW7-NOTCH interactome: A ubiquitin proteasomal system-induced crosstalk modulating oncogenic transformation in human tissues. In Cancer Reports (Vol. 4, Issue 4). https://doi.org/10.1002/cnr2.1369
dc.identifier.issn25738348
dc.identifier.urihttps://www.doi.org/10.1002/cnr2.1369
dc.identifier.urihttp://hdl.handle.net/11718/25286-
dc.description.abstractBackground: Ubiquitin ligases or E3 ligases are well programmed to regulate molecular interactions that operate at a post-translational level. Skp, Cullin, F-box containing complex (or SCF complex) is a multidomain E3 ligase known to mediate the degradation of a wide range of proteins through the proteasomal pathway. The three-dimensional domain architecture of SCF family proteins suggests that it operates through a novel and adaptable "super-enzymatic" process that might respond to targeted therapeutic modalities in cancer. Recent findings: Several F-box containing proteins have been characterized either as tumor suppressors (FBXW8, FBXL3, FBXW8, FBXL3, FBXO1, FBXO4, and FBXO18) or as oncogenes (FBXO5, FBXO9, and SKP2). Besides, F-box members like ?TrcP1 and ?TrcP2, the ones with context-dependent functionality, have also been studied and reported. FBXW7 is a well-studied F-box protein and is a tumor suppressor. FBXW7 regulates the activity of a range of substrates, such as c-Myc, cyclin E, mTOR, c-Jun, NOTCH, myeloid cell leukemia sequence-1 (MCL1), AURKA, NOTCH through the well-known ubiquitin-proteasome system (UPS)-mediated degradation pathway. NOTCH signaling is a primitive pathway that plays a crucial role in maintaining normal tissue homeostasis. FBXW7 regulates NOTCH protein activity by controlling its half-life, thereby maintaining optimum protein levels in tissue. However, aberrations in the FBXW7 or NOTCH expression levels can lead to poor prognosis and detrimental outcomes in patients. Therefore, the FBXW7-NOTCH axis has been a subject of intense study and research over the years, especially around the interactome's role in driving cancer development and progression. Several studies have reported the effect of FBXW7 and NOTCH mutations on normal tissue behavior. The current review attempts to critically analyze these mutations prognostic value in a wide range of tumors. Furthermore, the review summarizes the recent findings pertaining to the FBXW7 and NOTCH interactome and its involvement in phosphorylation-related events, cell cycle, proliferation, apoptosis, and metastasis. Conclusion: The review concludes by positioning FBXW7 as an effective diagnostic marker in tumors and by listing out recent advancements made in cancer therapeutics in identifying protocols targeting the FBXW7-NOTCH aberrations in tumors. � 2021 The Authors. Cancer Reports published by Wiley Periodicals LLC.
dc.language.isoen_US
dc.publisherJohn Wiley and Sons Inc
dc.relation.ispartofCancer Reports
dc.subjectcancer
dc.subjectdiagnostic markers
dc.subjectE3 ligase
dc.subjectFBXW7
dc.subjectmutation
dc.subjectNOTCH
dc.subjectSCF
dc.subjecttherapeutics
dc.titleThe FBXW7-NOTCH interactome: A ubiquitin proteasomal system-induced crosstalk modulating oncogenic transformation in human tissues
dc.typeReview
dc.rights.licenseCC BY
dc.contributor.affiliationIndian Institute of Management Ahmedabad (IIMA), Ahmedabad, Gujarat 380015, India
dc.contributor.affiliationDepartment of Biotechnology, School of Engineering & Technology (SET), Sharda University, Greater Noida, Uttar Pradesh 201310, India
dc.contributor.affiliationDepartment of Pharmacology and Therapeutics, College of Medicine and Health Sciences, United Arab Emirates University, Al Ain, 17666, United Arab Emirates
dc.contributor.affiliationDepartment of Life sciences, School of Basic Science & Research (SBSR), Sharda University, Greater Noida, Uttar Pradesh 201310, India
dc.contributor.affiliationDepartment of Medical Biochemistry and Microbiology, Uppsala University, Uppsala, Sweden
dc.contributor.affiliationDepartment of Chemistry, University of Petroleum & Energy Studies, Dehradun, 248007, India
dc.contributor.affiliationDepartment of Life Sciences, School of Pharmacy, International Medical University (IMU), Bukit Jalil, Kuala Lumpur, 57000, Malaysia
dc.contributor.affiliationSchool of Pharmacy, Suresh Gyan Vihar University, Jagatpura, Jaipur, 302017, India
dc.contributor.affiliationSchool of Pharmaceutical Sciences, Lovely Professional University, Phagwara, Punjab 144411, India
dc.contributor.affiliationCentre for Inflammation, Centenary InstituteNSW 2050, Australia
dc.contributor.affiliationSchool of Life Sciences, Faculty of Science, University of Technology Sydney2007, Australia
dc.contributor.affiliationPriority Research Centre for Healthy Lungs, Hunter Medical Research Institute (HMRI), University of Newcastle, New Lambton HeightsNSW 2308, Australia
dc.contributor.affiliationIndian Scientific Education and Technology Foundation, Lucknow, Uttar Pradesh 226002, India
dc.contributor.affiliationDepartment of Applied Physics, School of Science, Aalto University, Espoo, Finland
dc.contributor.affiliationDiscipline of Pharmacy, Graduate School of Health, University of Technology SydneyNSW 2007, Australia
dc.contributor.institutionauthorKar, R., Indian Institute of Management Ahmedabad (IIMA), Ahmedabad, Gujarat 380015, India
dc.contributor.institutionauthorJha, S.K., Department of Biotechnology, School of Engineering & Technology (SET), Sharda University, Greater Noida, Uttar Pradesh 201310, India
dc.contributor.institutionauthorOjha, S., Department of Pharmacology and Therapeutics, College of Medicine and Health Sciences, United Arab Emirates University, Al Ain, 17666, United Arab Emirates
dc.contributor.institutionauthorSharma, A., Department of Life sciences, School of Basic Science & Research (SBSR), Sharda University, Greater Noida, Uttar Pradesh 201310, India
dc.contributor.institutionauthorDholpuria, S., Department of Life sciences, School of Basic Science & Research (SBSR), Sharda University, Greater Noida, Uttar Pradesh 201310, India
dc.contributor.institutionauthorRaju, V.S.R., Department of Medical Biochemistry and Microbiology, Uppsala University, Uppsala, Sweden
dc.contributor.institutionauthorPrasher, P., Department of Chemistry, University of Petroleum & Energy Studies, Dehradun, 248007, India
dc.contributor.institutionauthorChellappan, D.K., Department of Life Sciences, School of Pharmacy, International Medical University (IMU), Bukit Jalil, Kuala Lumpur, 57000, Malaysia
dc.contributor.institutionauthorGupta, G., School of Pharmacy, Suresh Gyan Vihar University, Jagatpura, Jaipur, 302017, India
dc.contributor.institutionauthorKumar Singh, S., School of Pharmaceutical Sciences, Lovely Professional University, Phagwara, Punjab 144411, India
dc.contributor.institutionauthorPaudel, K.R., Centre for Inflammation, Centenary InstituteNSW 2050, Australia, School of Life Sciences, Faculty of Science, University of Technology Sydney2007, Australia
dc.contributor.institutionauthorHansbro, P.M., Centre for Inflammation, Centenary InstituteNSW 2050, Australia, School of Life Sciences, Faculty of Science, University of Technology Sydney2007, Australia, Priority Research Centre for Healthy Lungs, Hunter Medical Research Institute (HMRI), University of Newcastle, New Lambton HeightsNSW 2308, Australia
dc.contributor.institutionauthorKumar Singh, S., Indian Scientific Education and Technology Foundation, Lucknow, Uttar Pradesh 226002, India
dc.contributor.institutionauthorRuokolainen, J., Department of Applied Physics, School of Science, Aalto University, Espoo, Finland
dc.contributor.institutionauthorKesari, K.K., Department of Applied Physics, School of Science, Aalto University, Espoo, Finland
dc.contributor.institutionauthorDua, K., Centre for Inflammation, Centenary InstituteNSW 2050, Australia, Priority Research Centre for Healthy Lungs, Hunter Medical Research Institute (HMRI), University of Newcastle, New Lambton HeightsNSW 2308, Australia, Discipline of Pharmacy, Graduate School of Health, University of Technology SydneyNSW 2007, Australia
dc.contributor.institutionauthorJha, N.K., Department of Biotechnology, School of Engineering & Technology (SET), Sharda University, Greater Noida, Uttar Pradesh 201310, India
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dc.identifier.doi10.1002/cnr2.1369
dc.identifier.issue4
dc.identifier.volume4
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