Please use this identifier to cite or link to this item: http://hdl.handle.net/11718/25367
Full metadata record
DC FieldValueLanguage
dc.contributor.authorKar R.
dc.contributor.authorJha N.K.
dc.contributor.authorJha S.K.
dc.contributor.authorSharma A.
dc.contributor.authorDholpuria S.
dc.contributor.authorAsthana N.
dc.contributor.authorChaurasiya K.
dc.contributor.authorSingh V.K.
dc.contributor.authorBurgee S.
dc.contributor.authorNand P.
dc.date.accessioned2022-02-11T10:16:06Z-
dc.date.available2022-02-11T10:16:06Z-
dc.date.issued2019
dc.identifier.citationKar, R., Jha, N. K., Jha, S. K., Sharma, A., Dholpuria, S., Asthana, N., Chaurasiya, K., Singh, V. K., Burgee, S., & Nand, P. (2019). A 揘OTCH� deeper into the epithelial-to-mesenchymal transition (EMT) program in breast cancer. In Genes (Vol. 10, Issue 12). https://doi.org/10.3390/genes10120961
dc.identifier.issn20734425
dc.identifier.urihttps://www.doi.org/10.3390/genes10120961
dc.identifier.urihttp://hdl.handle.net/11718/25367-
dc.description.abstractNotch signaling is a primitive signaling pathway having various roles in the normal origin and development of each multicellular organisms. Therefore, any aberration in the pathway will inevitably lead to deadly outcomes such as cancer. It has now been more than two decades since Notch was acknowledged as an oncogene in mouse mammary tumor virus-infected mice. Since that discovery, activated Notch signaling and consequent up-regulation of tumor-promoting Notch target genes have been observed in human breast cancer. Moreover, consistent over-expression of Notch ligands and receptors has been shown to correlate with poor prognosis in human breast cancer. Notch regulates a number of key processes during breast carcinogenesis, of which, one key phenomenon is epithelial杕esenchymal transition (EMT). EMT is a key process for large-scale cell movement during morphogenesis at the time of embryonic development. Cancer cells aided by transcription factors usurp this developmental program to execute the multi-step process of tumorigenesis and metastasis. In this review, we recapitulate recent progress in breast cancer research that has provided new perceptions into the molecular mechanisms behind Notch-mediated EMT regulation during breast tumorigenesis. � 2019 by the authors. Licensee MDPI, Basel, Switzerland.
dc.language.isoen_US
dc.publisherMDPI AG
dc.relation.ispartofGenes
dc.subjectBreast cancer
dc.subjectCytokine
dc.subjectEMT
dc.subjectHypoxia
dc.subjectInvasion
dc.subjectMetastasis
dc.subjectNotch
dc.subjectPI3K/Akt
dc.subjectSignaling pathway
dc.titleA "NOTCH" deeper into the epithelial-to-mesenchymal transition (EMT) program in breast cancer
dc.typeReview
dc.rights.licenseCC BY
dc.contributor.affiliationIndian Institute of Management Ahmedabad (IIMA)Gujarat 380015, India
dc.contributor.affiliationDepartment of Biotechnology, School of Engineering & Technology (SET), Sharda University, Greater Noida, 201306, India
dc.contributor.affiliationDepartment of Life Science, School of Basic Science & Research (SBSR), Sharda University, Greater Noida, 201306, India
dc.contributor.affiliationNational Centre of Experimental Mineralogy & Petrology (NCEMP), University of Allahabad, Prayagraj, 2l1002, India
dc.contributor.institutionauthorKar, R., Indian Institute of Management Ahmedabad (IIMA)Gujarat 380015, India
dc.contributor.institutionauthorJha, N.K., Department of Biotechnology, School of Engineering & Technology (SET), Sharda University, Greater Noida, 201306, India
dc.contributor.institutionauthorJha, S.K., Department of Biotechnology, School of Engineering & Technology (SET), Sharda University, Greater Noida, 201306, India
dc.contributor.institutionauthorSharma, A., Department of Life Science, School of Basic Science & Research (SBSR), Sharda University, Greater Noida, 201306, India
dc.contributor.institutionauthorDholpuria, S., Department of Life Science, School of Basic Science & Research (SBSR), Sharda University, Greater Noida, 201306, India
dc.contributor.institutionauthorAsthana, N., National Centre of Experimental Mineralogy & Petrology (NCEMP), University of Allahabad, Prayagraj, 2l1002, India
dc.contributor.institutionauthorChaurasiya, K., Department of Biotechnology, School of Engineering & Technology (SET), Sharda University, Greater Noida, 201306, India
dc.contributor.institutionauthorSingh, V.K., Department of Biotechnology, School of Engineering & Technology (SET), Sharda University, Greater Noida, 201306, India
dc.contributor.institutionauthorBurgee, S., Department of Life Science, School of Basic Science & Research (SBSR), Sharda University, Greater Noida, 201306, India
dc.contributor.institutionauthorNand, P., Department of Biotechnology, School of Engineering & Technology (SET), Sharda University, Greater Noida, 201306, India
dc.description.scopusid57193338860
dc.description.scopusid55109018100
dc.description.scopusid56425051500
dc.description.scopusid57225853834
dc.description.scopusid57193092220
dc.description.scopusid36843825000
dc.description.scopusid57211965222
dc.description.scopusid57211967844
dc.description.scopusid57211965524
dc.description.scopusid6506991350
dc.identifier.doi10.3390/genes10120961
dc.identifier.issue12
dc.identifier.volume10
Appears in Collections:Open Access Journal Articles

Files in This Item:
File SizeFormat 
a_notch_deeper_2019.pdf1.19 MBAdobe PDFView/Open


Items in IIMA Institutional Repository are protected by copyright, with all rights reserved, unless otherwise indicated.