Please use this identifier to cite or link to this item: http://hdl.handle.net/11718/25730
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dc.contributor.authorBohora, Shomu-
dc.contributor.authorMumtaz, Zeeshan-
dc.contributor.authorPhadke, Milind-
dc.contributor.authorBhute, Vishnu-
dc.contributor.authorBhatia, Varun-
dc.contributor.authorVora, Amit-
dc.contributor.authorNaik, Ajay-
dc.contributor.authorNabar, Ashish-
dc.contributor.authorJankharia, Bhavin-
dc.contributor.authorVaideeswar, Pradeep-
dc.contributor.authorPanicker, Gopi-
dc.contributor.authorBhure, Ujwal-
dc.contributor.authorLokhandwala, Yash-
dc.date.accessioned2022-07-13T10:25:31Z-
dc.date.available2022-07-13T10:25:31Z-
dc.date.issued2022-
dc.identifier.citationBohora, S., Mumtaz, Z., Phadke, M., Bhute, V., Bhatia, V., Vora, A., Naik, A., Nabar, A., Jankharia, B., Vaideeswar, P., Panicker, G., Bhure, U., & Lokhandwala, Y. (2022). Long-term, real world experience of ventricular tachycardia and granulomatous cardiomyopathy. Indian Pacing and Electrophysiology Journal, 22(4), 169–178. https://doi.org/10.1016/j.ipej.2022.04.001en_US
dc.identifier.issn0972-6292-
dc.identifier.urihttp://hdl.handle.net/11718/25730-
dc.description.abstractBackground Granulomatous cardiomyopathy (GCM) is relatively uncommon in patients presenting with ventricular tachycardia (VT). Sarcoidosis and tuberculosis are the most common causes of GCM with VT. The aim of study was to evaluate their clinical characteristics and the long-term outcomes. Methods We retrospectively analyzed patients from March 2004 to January 2020, presenting with VT and subsequently diagnosed to have GCM. Patients were divided into three groups (sarcoid, tuberculosis and indeterminate) based on serologic tests, imaging and histopathology. The response to anti-arrhythmic and disease specific therapy on long-term follow-up were analyzed. Results There were 52 patients, comprising 27 males and 25 females, age 40 ± 10 years. The follow-up period was 5.9 ± 3.9 years. Sarcoidosis was diagnosed in 20 (38%); tuberculosis (TB) in 15(29%) and 17(33%) patients were indeterminate. Left ventricular ejection fraction (LVEF) of the entire cohort was 0.45 ± 0.14. Erythrocyte Sedimentation Rate(ESR) was found to be significantly higher in TB(43.6 ± 18.4) patients vs sarcoid(18.9 ± 6.7)p < 0.0001, but not the indeterminate group (36.2 ± 21.1), p = 0.3. Implantable Cardioverter Defibrillator (ICD) implantation was performed in 12/20(60%) patients in the sarcoid group, in 4/15(27%) patients in the TB group and in 10/17(59%) patients in the indeterminate group. At a mean follow-up of six years, VT recurrences were noted in 6, 2, and 7 patients in the sarcoid, TB and indeterminate groups respectively. Conclusion Despite the advances in diagnostic modalities for tuberculosis and sarcoidosis, in real-world practice, almost one-third of the patients with VT and GCM have uncertain etiology. Long term outcomes of patients presenting with GCM and VT with mild left ventricle dysfunction treated appropriately seems favorable.en_US
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.ispartofIndian Pacing and Electrophysiology Journalen_US
dc.subjectSarcoidosisen_US
dc.subjectTuberculosisen_US
dc.subjectVentricular tachycardiaen_US
dc.subjectCardiac imagingen_US
dc.titleLong-term, real world experience of ventricular tachycardia and granulomatous cardiomyopathyen_US
dc.typeArticleen_US
Appears in Collections:Open Access Journal Articles



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