Classification of pathological stages of prostate cancer using penalized splines
Date
2010-10-29Author
Banerjee, Tathagata
Maiti, Tapabrata
Mukhopadhyay, Pushpal
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We propose a penalized splines (P-splines) based method to predict the pathological stage of localized prostate cancer. A combination
of prostate-specific antigen, Gleason histological score, and clinical stage from a cohort study of 834 prostate cancer patients
are used to build the P-splines model. It turns out that the proposed methodology results in improved prediction of pathological
stage compared to usual logistic regression after removing a few outliers. The improvement is shown to be statistically signifi-
cant. Receiver-operating characteristic (ROC) curve is drawn and we show that the increase in area under the ROC curve over the
commonly used logistic regression based classification method is also statistically significant.
© 2005 Elsevier B.V. All rights reserved.
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