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dc.contributor.authorJha N.K.
dc.contributor.authorOjha S.
dc.contributor.authorJha S.K.
dc.contributor.authorDureja H.
dc.contributor.authorSingh S.K.
dc.contributor.authorShukla S.D.
dc.contributor.authorChellappan D.K.
dc.contributor.authorGupta G.
dc.contributor.authorBhardwaj S.
dc.contributor.authorKumar N.
dc.contributor.authorJeyaraman M.
dc.contributor.authorJain R.
dc.contributor.authorMuthu S.
dc.contributor.authorKar R.
dc.contributor.authorKumar D.
dc.contributor.authorGoswami V.K.
dc.contributor.authorRuokolainen J.
dc.contributor.authorKesari K.K.
dc.contributor.authorSingh S.K.
dc.contributor.authorDua K.
dc.date.accessioned2022-02-11T10:13:47Z
dc.date.available2022-02-11T10:13:47Z
dc.date.issued2021
dc.identifier.citationJha, N. K., Ojha, S., Jha, S. K., Dureja, H., Singh, S. K., Shukla, S. D., Chellappan, D. K., Gupta, G., Bhardwaj, S., Kumar, N., Jeyaraman, M., Jain, R., Muthu, S., Kar, R., Kumar, D., Goswami, V. K., Ruokolainen, J., Kesari, K. K., Singh, S. K., & Dua, K. (2021). Evidence of Coronavirus (CoV) Pathogenesis and Emerging Pathogen SARS-CoV-2 in the Nervous System: A Review on Neurological Impairments and Manifestations. In Journal of Molecular Neuroscience (Vol. 71, Issue 11). https://doi.org/10.1007/s12031-020-01767-6
dc.identifier.issn8958696
dc.identifier.urihttps://www.doi.org/10.1007/s12031-020-01767-6
dc.identifier.urihttp://hdl.handle.net/11718/25180
dc.description.abstractThe coronavirus disease 2019 (COVID-19) pandemic is an issue of global significance that has taken the lives of many across the world. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the virus responsible for its pathogenesis. The pulmonary manifestations of COVID-19 have been well described in the literature. Initially, it was thought to be limited to the respiratory system; however, we now recognize that COVID-19 also affects several other organs, including the nervous system. Two similar human coronaviruses (CoV) that cause severe acute respiratory syndrome (SARS-CoV-1) and Middle East respiratory syndrome (MERS-CoV) are also known to cause disease in the nervous system. The neurological manifestations of SARS-CoV-2 infection are growing rapidly, as evidenced by several reports. There are several mechanisms responsible for such manifestations in the nervous system. For instance, post-infectious immune-mediated processes, direct virus infection of the central nervous system (CNS), and virus-induced hyperinflammatory and hypercoagulable states are commonly involved. Guillain-Barr� syndrome (GBS) and its variants, dysfunction of taste and smell, and muscle injury are numerous examples of COVID-19 PNS (peripheral nervous system)燿isease. Likewise, hemorrhagic and ischemic stroke, encephalitis, meningitis, encephalopathy acute disseminated encephalomyelitis, endothelialitis, and venous sinus thrombosis are some instances of COVID-19 CNS disease. Due to multifactorial and complicated pathogenic mechanisms, COVID-19 poses a large-scale threat to the whole nervous system. A complete understanding of SARS-CoV-2 neurological impairments is still lacking, but our knowledge base is rapidly expanding. Therefore, we anticipate that this comprehensive review will provide valuable insights and facilitate the work of neuroscientists in unfolding different neurological dimensions of COVID-19燼nd other CoV associated abnormalities. � 2021, The Author(s), under exclusive licence to Springer Science+Business Media, LLC part of Springer Nature.
dc.language.isoen_US
dc.publisherHumana Press Inc.
dc.relation.ispartofJournal of Molecular Neuroscience
dc.subjectACE2
dc.subjectCerebrovascular disease
dc.subjectCoronavirus (CoV)
dc.subjectCOVID-19
dc.subjectGuillain-Barr� syndrome (GBS)
dc.subjectMultiple sclerosis
dc.subjectNervous system
dc.subjectNeuropathogenesis
dc.subjectSARS-CoV-2
dc.titleEvidence of Coronavirus (CoV) Pathogenesis and Emerging Pathogen SARS-CoV-2 in the Nervous System: A Review on Neurological Impairments and Manifestations
dc.typeReview
dc.rights.licenseCC BY
dc.contributor.affiliationDepartment of Biotechnology, School of Engineering & Technology (SET), Sharda University, Greater Noida, UP 201310, India
dc.contributor.affiliationDepartment of Pharmacology and Therapeutics, College of Medicine and Health Sciences, PO Box - 17666, United Arab Emirates University, Al Ain, United Arab Emirates
dc.contributor.affiliationFaculty of Pharmaceutical Sciences, Maharshi Dayanand University, Rohtak, India
dc.contributor.affiliationSchool of Pharmaceutical Sciences, Lovely Professional UniversityPunjab, India
dc.contributor.affiliationPriority Research Centre for Healthy Lungs, Hunter Medical Research Institute (HMRI), University of Newcastle, New Lambton Heights, Newcastle, NSW 2305, Australia
dc.contributor.affiliationDepartment of Life Sciences, School of Pharmacy, International Medical University, Bukit Jalil, Kuala Lumpur, 57000, Malaysia
dc.contributor.affiliationSchool of Pharmacy, Suresh Gyan Vihar University, Mahal Road, Jagatpura, Jaipur, India
dc.contributor.affiliationDepartment of Biotechnology, HIMT, CCS University, Greater Noida, UP, India
dc.contributor.affiliationDepartment of Chemistry, University of Delhi, Delhi, 110007, India
dc.contributor.affiliationDepartment of Orthopaedics, School of Medical Sciences and Research, Sharda University, Greater Noida, UP 201310, India
dc.contributor.affiliationSchool of Medical Sciences and Research, Sharda University, Greater Noida, UP 201310, India
dc.contributor.affiliationResearch Associate, Orthopaedic Research Group, Coimbatore, Tamil Nadu, India
dc.contributor.affiliationIndian Institute of Management Ahmedabad (IIMA)Gujarat 380015, India
dc.contributor.affiliationAmity Institute of Molecular Medicine and Stem Cell Research (AIMMSCR), Amity University Uttar Pradesh, Noida, 201313, India
dc.contributor.affiliationDepartment of Biological Sciences, School of Basic and Applied Sciences, G.D. Goenka University, G.D. Goenka Education City Sohna Gurugram RoadHaryana 122103, India
dc.contributor.affiliationDepartment of Applied Physics, School of Science, Aalto University, Espoo, 00076, Finland
dc.contributor.affiliationCentre of Biomedical Research, SGPGI Campus, Lucknow, UP 226014, India
dc.contributor.affiliationIndian Scientific Education and Technology Foundation, Lucknow, UP 226002, India
dc.contributor.affiliationDiscipline of Pharmacy, Graduate School of Health, University of Technology Sydney, Sydney, NSW 2007, Australia
dc.contributor.affiliationSchool of Pharmaceutical Sciences, Shoolini University of Biotechnology and Management Sciences, Post box no. 9, Solan, Himachal Pradesh 173229, India
dc.contributor.institutionauthorJha, N.K., Department of Biotechnology, School of Engineering & Technology (SET), Sharda University, Greater Noida, UP 201310, India
dc.contributor.institutionauthorOjha, S., Department of Pharmacology and Therapeutics, College of Medicine and Health Sciences, PO Box - 17666, United Arab Emirates University, Al Ain, United Arab Emirates
dc.contributor.institutionauthorJha, S.K., Department of Biotechnology, School of Engineering & Technology (SET), Sharda University, Greater Noida, UP 201310, India
dc.contributor.institutionauthorDureja, H., Faculty of Pharmaceutical Sciences, Maharshi Dayanand University, Rohtak, India
dc.contributor.institutionauthorSingh, S.K., School of Pharmaceutical Sciences, Lovely Professional UniversityPunjab, India
dc.contributor.institutionauthorShukla, S.D., Priority Research Centre for Healthy Lungs, Hunter Medical Research Institute (HMRI), University of Newcastle, New Lambton Heights, Newcastle, NSW 2305, Australia
dc.contributor.institutionauthorChellappan, D.K., Department of Life Sciences, School of Pharmacy, International Medical University, Bukit Jalil, Kuala Lumpur, 57000, Malaysia
dc.contributor.institutionauthorGupta, G., School of Pharmacy, Suresh Gyan Vihar University, Mahal Road, Jagatpura, Jaipur, India
dc.contributor.institutionauthorBhardwaj, S., Department of Biotechnology, HIMT, CCS University, Greater Noida, UP, India
dc.contributor.institutionauthorKumar, N., Department of Chemistry, University of Delhi, Delhi, 110007, India
dc.contributor.institutionauthorJeyaraman, M., Department of Orthopaedics, School of Medical Sciences and Research, Sharda University, Greater Noida, UP 201310, India
dc.contributor.institutionauthorJain, R., School of Medical Sciences and Research, Sharda University, Greater Noida, UP 201310, India
dc.contributor.institutionauthorMuthu, S., Research Associate, Orthopaedic Research Group, Coimbatore, Tamil Nadu, India
dc.contributor.institutionauthorKar, R., Indian Institute of Management Ahmedabad (IIMA)Gujarat 380015, India
dc.contributor.institutionauthorKumar, D., Amity Institute of Molecular Medicine and Stem Cell Research (AIMMSCR), Amity University Uttar Pradesh, Noida, 201313, India
dc.contributor.institutionauthorGoswami, V.K., Department of Biological Sciences, School of Basic and Applied Sciences, G.D. Goenka University, G.D. Goenka Education City Sohna Gurugram RoadHaryana 122103, India
dc.contributor.institutionauthorRuokolainen, J., Department of Applied Physics, School of Science, Aalto University, Espoo, 00076, Finland
dc.contributor.institutionauthorKesari, K.K., Department of Applied Physics, School of Science, Aalto University, Espoo, 00076, Finland
dc.contributor.institutionauthorSingh, S.K., Centre of Biomedical Research, SGPGI Campus, Lucknow, UP 226014, India, Indian Scientific Education and Technology Foundation, Lucknow, UP 226002, India
dc.contributor.institutionauthorDua, K., Priority Research Centre for Healthy Lungs, Hunter Medical Research Institute (HMRI), University of Newcastle, New Lambton Heights, Newcastle, NSW 2305, Australia, Discipline of Pharmacy, Graduate School of Health, University of Technology Sydney, Sydney, NSW 2007, Australia, School of Pharmaceutical Sciences, Shoolini University of Biotechnology and Management Sciences, Post box no. 9, Solan, Himachal Pradesh 173229, India
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dc.identifier.doi10.1007/s12031-020-01767-6


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