Application of pooled testing in estimating the prevalence of COVID-19

Abstract

Testing at a mass scale has been widely accepted as an effective way to contain the spread of the SARS-CoV-2 Virus. In the initial stages, the shortage of test kits severely restricted mass-scale testing. Pooled testing was offered as a partial solution to this problem. However, it is a relatively lesser-known fact that pooled testing can also result in significant gains, both in terms of cost savings as well as measurement accuracy, in prevalence estimation surveys. We review here the statistical theory of pooled testing for screening as well as for prevalence estimation. We study the impact of the diagnostic errors, and misspecification of the sensitivity and the specificity on the performances of the pooled as well as individual testing procedures. Our investigation clarifies some of the issues hotly debated in the context of COVID-19 and shows the potential gains for the Indian Council for Medical Research (ICMR) in using a pooled sampling for their upcoming COVID-19 prevalence surveys. � 2021, The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.